Domperidone+Pantoprazole is used in the treatment of gastroesophageal reflux disease (acid reflux) and Peptic ulcer disease. it is a combination of two medicines: Domperidone and Pantoprazole. Domperidone is a prokinetic which works on the upper digestive tract to increase the movement of the stomach and intestines, allowing the food to move more easily through the stomach. Pantoprazole is a proton pump inhibitor (PPI) which works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn. Take it one hour before the meal, preferably in the morning. It is a well-tolerated medicine and provides relief for a long time. Long-term use can cause weak bones and deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.